Cell Biology/Signaling Matrix Metalloproteinase-10 Is Upregulated by Thrombin in Endothelial Cells and Increased in Patients With Enhanced Thrombin Generation

Received December 12, 2008; revision accepted September 8, 2009. From the Atherothrombosis Research Laboratory, Division of Cardiovascular Sciences (J.O., J.A.R., C.R., S.M.d.L., J.B., J.A.P.), Center for Applied Medical Research (P.S., M.V.), University of Navarra, Pamplona, Spain; Centro de Investigación Cardiovascular (CSIC-ICCC) (O.C., R.R.-C., C.R., J.M.-G.), Hospital de la Santa Creu I Sant Pau, Barcelona, Spain; the Department of Haemotherapy and Haemostasis (J.C.R.), Hospital Clinic, University of Barcelona, Spain; and the Hematology Service (J.A.P.), University Clinic, University of Navarra, Pamplona, Spain. J.M.-G. and J.A.P. contributed equally to this study. Correspondence to José A. Páramo, Atherothrombosis Research Laboratory, Division of Cardiovascular Science, CIMA-University of Navarra, Avda. Pio XII, 55 31008 Pamplona, Navarra, Spain. E-mail [email protected] José Martı́nez-González, Centro de Investigación Cardiovascular (CSIC-ICCC), Hospital de la Santa Creu I Sant Pau, Sant Antoni M Claret 167, 08025 Barcelona, Spain. E-mail [email protected]. © 2009 American Heart Association, Inc.